Forskolin: Its Therapeutic Applications
نویسنده
چکیده
Medicinal herbs are moving from fringe to mainstream use with a greater number of people seeking remedies.Forskolin, is a diterpene, the main active ingredient in the ayurvedic herb Coleus forskohliihas been used in India since prehistoric times in ayurvedic traditional medicine.Coleus forskohliiis a perennial aromatic herb found in subtropical regions of India, Nepal and Srilanka.Forskolin activates the enzyme adenylatecyclase, results in increased cAMP in cells. Cyclic AMP is involved in several biological processes, including inhibition of platelet activation, reduced release of histamine, increased force of contraction of the heart, relaxation of the arteries and other smooth muscles, and increased lipolysis and also cures various diseases like asthma, eczema, psoriasis, angina, obesity,hypertension, glaucoma,acts as antimetastatic and protect cells from UV induced damage, ageing of skin. Studies are warranted to understand the effect of forskolin on various diseases for its utility in therapeutics.
منابع مشابه
Forskolin attenuates the paraoxon-induced hyperexcitability in snail neurons
Introduction: Since organophosphorus compounds (OP) are toxic and designed to destroy insects and pest species, there are many hazards associated with their use. Although, the main target site of these compounds is acetylcholinesterase (AChE), however it has become increasingly evident that OPs have also other direct effects on cellular processes. In the present study, the effects of low con...
متن کاملNanocomposite Based on Albumin Protein and Review of Its Applications in Medical Engineering
Albumin is a protein macromolecule that it has been attractive since the early 20th century and has several therapeutic applications. Albumin is an aboundant serum with good biocompatibility, hematopoiesis and biodegradability in blood. The existence of multiple functional groups makes it possible to carry significant amounts of therapeutic and diagnostic factors, as well as targeting factors. ...
متن کاملEffect of Different Concentrations of Forskolin Along with Mature Granulosa Cell Co-Culturing on Mouse Embryonic Stem Cell Differentiation into Germ-Like Cells
Background: Germ cell development processes are influenced by soluble factors and intercellular signaling events between them and the neighboring somatic cells. More insight into the molecular biology of the germ cell development from embryonic stem (ES) cells and investigation of appropriate factors, specifically those targeting differentiation process, is of great importance. In this study, w...
متن کاملBiological characteristics of Stem Cells from Human Exfoliated Deciduous Teeth (SHEDs) and its therapeutic applications in regenerative medicine
Stem cells isolated from human exfoliated deciduous teeth (SHEDs) are multipotent mesenchymal stem cells that are isolated from dental pulp tissues. These cells have a high proliferative capacity, multipotential ability, immunomodulatory function, and minimal risk of oncogenesis. Recent studies have shown that SHEDs are a feasible cell source for cell therapy and regenerative medicine.
متن کاملThe relaxant effect of Nigella sativa on smooth muscles, its possible mechanisms and clinical applications
Nigella sativa (N. sativa) is a spice plant which has been traditionally used for culinary and medicinal purposes. Different therapeutic properties including the beneficial effects on asthma and dyspnea, digestive and gynecology disorders have been described for the seeds of N. sativa. There is evidence of the relaxant effects of this plant and some of its constituents on different types of smo...
متن کاملProtective effect of forskolin on diabetes induced nephrophaty via antioxidant activity
The present study aimed to investigate the role of adenylyl cyclase activator in preventing diabetic nephropathy via antioxidant activity in rats. Biochemical parameters were performed to confirm Streptozotocin induced nephropathy in rats. Male Wistar rats were used in the present study to reduce the effect of estrogen. Rats were subjected to high fat diet (HFD) for two weeks followed by low do...
متن کامل